Ethanol → 5,7-Dimethyl-1,2,3,7-tetrahydroimidazolo[1,2-a]pyridine-6,8-dicarboxylic acid diethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:11])[CH2:5][C:6]([CH:8]=CC)=O)[CH3:2].[C:12]([CH:17]=[C:18]1[NH:22][CH2:21][CH2:20][NH:19]1)([O:14][CH2:15][CH3:16])=[O:13].[CH2:23](O)[CH3:24]>>[CH2:1]([O:3][C:4]([C:5]1[CH:6]([CH3:8])[C:17]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:18]2[NH:19][CH2:20][CH2:21][N:22]2[C:23]=1[CH3:24])=[O:11])[CH3:2]Participants
4
Procedure
Upon heating a solution of 6 g of ethylideneacetoacetic acid ethyl ester and 6 g of 2-carbethoxymethylideneimidazolidine in 50 ml of ethanol for 10 hours, 5,7-dimethyl-1,2,3,7-tetrahydroimidazolo[1,2-a]pyridine-6,8-dicarboxylic acid diethyl ester of melting point 138° (ethanol) is obtained.
Sources & evidence
- ORD record
- ord-b49af5ec155c4fb39558919372a64ef7
- Source dataset
- uspto-grants-1977_10
- Patent number
- US04053614
Reaction notes
Loading…