Nitrobenzene → HCID 178479343, compound

Participants

Reaction Steps

A mixture of 1-(p-(2,2-dichlorocyclopropyl)phenyl)- 3-cyanoguanidine (8.3 g.), hexamethylenediamine dihydrochloride (2.8 g.) and nitrobenzene (30 g.) was stirred and heated (at 140°-145° C.) for four hours, cooled and filtered. The filter cake was slurried in a mixture of acetone (75 g.) and acetic acid (7 g.), then hot ethanol (300 g.), affording a light tan solid (2.3 g.), whose thin layer chromatogram showed a substantial amount of 1,1'-hexamethylenebis(5-(p-(2,2-dichlorocyclopropyl)phenyl)biguanide) but also a substantial amount of impurity.

Provenance & Evidence