HCID 54272806, compound → 2-[1-beta-Bromoethyl-3-(5-trifluoromethylbenzothiazol-2-yl)-ureido]acetaldehyde

HRID 972936Notes

Reaction equation

HRID 972936 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([N:11]=[C:12]=[O:13])=[N:8][C:7]=2[CH:14]=1.[Br:17][CH2:18][CH2:19][NH:20][CH2:21][CH:22]=[O:23]>C1C=CC=CC=1>[Br:17][CH2:18][CH2:19][N:20]([CH2:21][CH:22]=[O:23])[C:12]([NH:11][C:9]1[S:10][C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:15])[F:16])=[CH:14][C:7]=2[N:8]=1)=[O:13]

Participants

4

Reactant 2

HCID 54272806HCID 54272806, compoundHCID 544616495-Trifluoromethylbenzothiazol-2-yl isocyanate

Product 1

HCID 539046292-[1-beta-Bromoethyl-3-(5-trifluoromethylbenzothiazol-2-yl)-ureido]acetaldehyde

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

5-Trifluoromethylbenzothiazol-2-yl isocyanate dimer (0.1 mole), the dimethyl acetal of 2-β-bromoethylaminoacetaldehyde (0.2 mole) and benzene (100 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The reaction mixture is stirred at ambient temperatures for a period of about one hour. After this time the reaction mixture is filtered, and the filtrate is stripped of solvent is yield the desired product the dimethyl acetal of 2-[1-β-bromoethyl-3-(5-trifluoromethylbenzothiazol-2-yl)ureido]acetaldehyde as the residue.

Workup

  1. customequipped with a mechanical stirrer
  2. filtrationAfter this time the reaction mixture is filtered

Sources & evidence

ORD record
ord-3be9e82fbb4341f9b8504f9dee27a921
Source dataset
uspto-grants-1977_10
Patent number
US04054574

Reaction notes

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