HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 9730Generated: October 28, 2026
Hydrochloric Acid → 3-(2-bromo-6-fluoro-phenyl)-7-(4,4-dioxo-3,4-dihydro-2H-4lambda*6*-benzo[1,4]oxathiin-6-ylamino)-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one
https://huagongshe.com/reaction/9730
Participants
| Role | Name | HCID | Charge |
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| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-(2-Bromo-6-fluorophenyl)-3,4-dihydro-7-methanesulphonyl-1-methylpyrimido[4,5-d]pyrimidin-2(1h)-one | HCID 21988150 | — |
| Reactant | 6-Amino-2,3-dihydro-1,4 | HCID 21988151 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 3-(2-bromo-6-fluoro-phenyl)-7-(4,4-dioxo-3,4-dihydro-2H-4lambda*6*-benzo[1,4]oxathiin-6-ylamino)-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one | HCID 10414745 | — |
Reaction Steps
83 mg 3-(2-bromo-6-fluorophenyl)-3,4-dihydro-7-methanesulphonyl-1-methyl-pyrimido[4,5-d]pyrimidin-2(1H)-one and 80 mg 6-Amino-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide (starting material h)) in 0.8 ml NMP were treated with 0.2 ml 2M HCl in ether and heated to 120° C. for 6 hrs. From this mixture 21 mg of the title product were isolated by preparative HPLC-MS (mp: 230–233° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07091345B2 |
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| Source dataset | uspto-grants-2006_08 |
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| ORD ID | ord-93ea8c40085e468c80b7e223c1b1aa11 |
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| Source note | uspto-grants-2006_08 |
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