Phosgene → 4,6-Dimethoxyisatoic anhydride

HRID 973053Notes

Reaction equation

HRID 973053 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:14])[C:6](=[C:10]([O:12][CH3:13])[CH:11]=1)[C:7]([OH:9])=[O:8].[C:15](Cl)(Cl)=[O:16]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[NH:14][C:15](=[O:16])[O:9][C:7](=[O:8])[C:6]2=[C:10]([O:12][CH3:13])[CH:11]=1

Participants

3

Reactant 2

HCID 6371PhosgeneHCID 116584562-Amino-4,6-dimethoxybenzoic acid

Product 1

HCID 116010104,6-Dimethoxyisatoic anhydride

Procedure

4,6-Dimethoxyisatoic anhydride is prepared from 4,6-dimethoxyanthranilic acid (H. Newman & R. Anzier, J. Org. Chem. 34, 3484 (1969)) and phosgene according to the method of E. C. Wagner and M. F. Fegley, Org. Synthesis 27, 45 (1947).

Workup

  1. customSynthesis 27, 45 (1947)

Sources & evidence

ORD record
ord-d5cff876f69e4742a2c21f26bcb1e12b
Source dataset
uspto-grants-1977_10
Patent number
US04054657

Reaction notes

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