Ammonia → 2-Nitropyridine-4-carboxamide

HRID 973059Notes

Reaction equation

HRID 973059 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][N:13]=1)[C:7](OC)=[O:8])([O-:3])=[O:2].[NH3:14]>>[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][N:13]=1)[C:7]([NH2:14])=[O:8])([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 13241119Methyl 2-nitropyridine-4-carboxylate

Product 1

HCID 132411182-Nitropyridine-4-carboxamide

Procedure

A mixture of 400 mg. of methyl 2-nitroisonicotinate and 2 ml. of 28% aqueous ammonia were stirred at room temperature for 1 hour. The solvent was distilled off, and the residue was recrystallized from ethanol-ether to give 348 mg. of the desired product.

Workup

  1. additionA mixture of 400 mg
  2. distillationThe solvent was distilled off
  3. customthe residue was recrystallized from ethanol-ether
  4. customto give 348 mg

Sources & evidence

ORD record
ord-b5ae9e9f39f64840852090ba2dc6d466
Source dataset
uspto-grants-1977_10
Patent number
US04054663

Reaction notes

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