Ethylamine → HCID 20321048, compound

HRID 973060Notes

Reaction equation

HRID 973060 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][N:13]=1)[C:7]([O:9]C)=O)([O-:3])=[O:2].[CH2:14]([NH2:16])[CH3:15]>>[CH2:14]([NH:16][C:7](=[O:9])[C:6]1[CH:11]=[CH:12][N:13]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[CH3:15]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 13241119Methyl 2-nitropyridine-4-carboxylate

Product 1

HCID 20321048HCID 20321048, compound

Procedure

A mixture of 500 mg. of methyl 2-nitroisonicotinate and 2 ml. of 70% ethylamine was stirred at room temperature for 5 hours. The reaction mixture was extracted with ethyl acetate. The extract was washed with water, dried and then the solvent was distilled off. The crystalline residue was recrystallized from ethyl acetate - n-hexane to give 328 mg. of the desired product.

Workup

  1. additionA mixture of 500 mg
  2. extractionThe reaction mixture was extracted with ethyl acetate
  3. washThe extract was washed with water
  4. customdried
  5. distillationthe solvent was distilled off
  6. customThe crystalline residue was recrystallized from ethyl acetate - n-hexane
  7. customto give 328 mg

Sources & evidence

ORD record
ord-7bfc1a88baff43ed9da729344e09ca50
Source dataset
uspto-grants-1977_10
Patent number
US04054663

Reaction notes

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