HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 9731Generated: October 28, 2026
Trifluoroacetic acid → 3-(2-Bromo-phenyl)-1-methyl-7-(4-methyl-3-oxo-3,4-dihydro-2h-benzo[1,4]thiazin-7-ylamino)-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one
https://huagongshe.com/reaction/9731
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 7-Amino-4-methyl-4h-benzo[1,4]thiazin-3-one | HCID 21877770 | — |
| Reactant | 3-(2-bromophenyl)-7-methanesulfonyl-3,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-2(1H)-one | HCID 21988153 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 3-(2-Bromo-phenyl)-1-methyl-7-(4-methyl-3-oxo-3,4-dihydro-2h-benzo[1,4]thiazin-7-ylamino)-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one | HCID 10481466 | — |
Reaction Steps
320 mg 3-(2-bromo-phenyl)-3,4-dihydro-7-methanesulphonyl-1-methylpyrimido-[4,5-d]pyrimidin-2(1H)-one and 626 mg 7-amino-4-methyl-4H-benzo[1,4]thiazin-3-one (starting material k)) in 4 ml NMP were treated with 92 mg TFA and heated to 140° C. for 12 hrs. The mixture was diluted with aqueous HCl and the precipitated product collected by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07091345B2 |
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| Source dataset | uspto-grants-2006_08 |
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| ORD ID | ord-f840b6ad1baf4e27939b43cc47ae75b9 |
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| Source note | uspto-grants-2006_08 |
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