4-Nitrophthalic acid anhydride → HCID 21400824, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 12.35 g of 1n-butyl-2-methylindole in 20 ml ethylacetate at 70° C, 11.6 g 4-nitrophthalic anhydride is added over 10 minutes. The reaction mixture is stirred under reflux at 80° C for C. hour and cooled to 20° C The crystalline solid thus obtained is filtered off, washed with a mixture of ethyl acetate and petroleum ether and dried in vacuo at 80° C to yield 19.6 g (86% of theory) of the two isomers 1-n-butyl-2-methyl-3-(2'-carboxy-4'-nitrobenzoyl) indole and 1-n-butyl-2-methyl-3-(2'-carboxy-5'-nitro-benzoyl)-indole having a melting point of 165°-167° C.

Provenance & Evidence