Isopropylamine → HCID 3697918, compound

Participants

Reaction Steps

30 ml of triethylamine are added to 32.5 g (0.156 mol) of 2-methyl-4,6-dichloro-5-nitro-pyrimidine. At -18° C, 3.5 g of isopropylamine (0.16 mol) are added dropwise and the mixture is then stirred for 11/4 hours at this temperature. The mixture is subsequently poured on 4 liters of water, the precipitate is filtered off with suction, and washed 3 times with water. The crude product is dried at 50° C and 11 Torr for 16 hours, to yield 26.4 g of 2-methyl-4-chloro-5-nitro-isopropylamino-pyrimidine with a melting point of 69°-72° C. The pure substance (recrystallised from hexane) melts at 77°-79° C.

Provenance & Evidence