反应详情

1.15 g (0.005 mol) of 2,4,6-trichloro-5-nitropyrimidine are dissolved in 50 ml of alcohol and the solution is then treated with 2.9 g (0.05 mol) of isopropylamine. The mixture is stirred for 3 hours at room temperature after the temperature has first risen to 35° C, and then it is evaporated. The residue is treated with 100 ml of water and extracted twice with ether. The ethereal extract is dried over MgSO4 for 4 hours, filtered, and evaporated, to yield 1.1 g of 2,4,6-tri-isopropylamino-5-nitro-pyrimidine as an oil; b.p. 185° C at 0.001 Torr.

1. customhas first risen to 35° C
2. customit is evaporated
3. additionThe residue is treated with 100 ml of water
4. extractionextracted twice with ether
5. extractionThe ethereal extract
6. dry with materialis dried over MgSO4 for 4 hours
7. filtrationfiltered
8. customevaporated