Hydrochloric Acid → HCID 178488465, compound

Participants

Reaction Steps

A mixture of 2 -(4-methoxyphenyl)-8H-pyrazolo[5,1-a]isoindol-8-one (100 mg), water (5 ml) and methanol (5ml) was stirred for one hour with sodium hydroxide (0.5 g). Within 5 minutes, a colorless solution has been produced. The mixture was then acidified to pH 3 with concentrated hydrochloric acid, cooled to 0° and filtered. The colorless crystalline residue was rinsed with water and air-dried. It was recrystallized from 33% aqueous ethanol (15 ml), recovery 80.7 mg (79%) of colorless crystals, mp 223°-225° dec, of 3-(2-carboxyphenyl)-5-(4-methoxyphenyl)pyrazole.

Provenance & Evidence