Water → 2,6-Diethyl-2,3,6-trimethylpiperidin-4-one

Participants

Reaction Conditions

Reaction Steps

First 14.7 g of powdered calcium chloride dihydrate and then 3 ml of water were added to an ice-cooled mixture of 39.2 g of 2,4,6-triethyl-2,6-dimethyl-1,2,5,6-tetrahydropyrimidine and 18.0g of methyl ethyl ketone. The resulting mixture was heated at 60° C with stirring for 15 hours made alkaline with 35% aqueous sodium hydroxide solution, and extracted with diethyl ether. The extract was dried over potassium carbonate and the ether was evaporated off. The residue was distilled under reduced pressure, to give 32.4 g of the desired product.

Provenance & Evidence