HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 7-bromoheptanoate → 7-{N-[4-hydroxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamido}heptanoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 7-bromoheptanoate | HCID 122490 | — |
| Reactant | Ethyl 7-bromohept-5-ynoate | HCID 15174663 | — |
| Reactant | N-[4-acetoxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamide | HCID 21401584 | — |
| Reactant | HCID 21401585 | HCID 21401585 | — |
| Reactant | ethyl 7-{N-[4-acetoxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamido}heptanoate | HCID 21401631 | — |
| Product | 7-{N-[4-hydroxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamido}heptanoic Acid | HCID 21401578 | — |
Reaction Steps
This compound is prepared by the procedure described in Example 2, Step I, except that N-[4-acetoxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamide is substituted for the N-[4-acetoxy-5-(4-fluorophenoxy)pentyl]methanesulfonamide and ethyl 7-bromoheptanoate is substituted for ethyl 7-bromo-5-heptynoate. The product is thus ethyl 7-{N-[4-acetoxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamido}heptanoate. The subsequent hydrolysis (Example 2, Step J) affords the subject compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04055596 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-05af4a35b53741a0a86223c8470cbfad |
| Source note | uspto-grants-1977_10 |