Water → 3-Oxo-17beta(1oxopropoxy)androst-4en-19-al

Participants

Reaction Steps

To a solution of 14 g of 19-hydroxy-17β-(1-oxopropoxy)androst-4-en-3-one in 1 liter of acetone cooled in an ice bath is added 13.3 ml of Jones reagent over one hour after which the reaction mixture is poured into a large volume of water and extracted with ether. The ether extract is dried over magnesium sulfate, filtered and the solvent removed. The residue is crystallized from acetone-hexane to give 3-oxo-17β(1-oxopropoxy)androst-4-en-19-al, M.P. 119°-121° C.

Provenance & Evidence