Iodine → HCID 12934766, compound

HRID 973223Notes

Reaction equation

HRID 973223 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[CH:3]=[CH:2]1.[NH:10]1[CH2:15][CH2:14][CH2:13][N:12]=[C:11]1[SH:16].[I:17]I.[I-].[K+]>CO.O>[IH:17].[NH:12]1[CH2:13][CH2:14][CH2:15][N:10]=[C:11]1[S:16][C:3]1[C:4]2[C:9](=[N:8][CH:7]=[CH:6][CH:5]=2)[NH:1][CH:2]=1

Participants

7

Reactant 4

HCID 807IodineHCID 4875Potassium IodideHCID 92221H-Pyrrolo(2,3-b)pyridineHCID 178527864HCID 178527864, compound

Product 1

HCID 12934766HCID 12934766, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent

Procedure

A mixture of 2.8 g 7-azaindole in 25 ml methanol and 3.5 g 1,4,5,6-tetrahydro-2-pyrimidinethiol in 50 ml methanol is added to a well-stirred solution of 7.6 g iodine and 15 g potassium iodide in 50 ml water. The mixture is stirred at room temperature for 14 hours and filtered. The precipitate is washed with water and ether and then recrystallised from water to give 3-(1,4,5,6-tetrahydro-2-pyrimidinylthio)-7-aza-indole hydriodide melting at 294°-295°.

Workup

  1. filtrationfiltered
  2. washThe precipitate is washed with water and ether
  3. customrecrystallised from water

Sources & evidence

ORD record
ord-57dadfd657b043f08d6f07aa4772f8d5
Source dataset
uspto-grants-1977_10
Patent number
US04055647

Reaction notes

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