Iodine → HCID 12934727, compound

Participants

Reaction Steps

A solution of 28.98 g of indole-2-carboxylic acid in 300 ml of methanol is added to a well-stirred solution of 90 g of potassium iodide and 45.6 g of iodine in 270 ml of water at room temperature. This mixture is further treated with a solution of 23.4 g of 1-methyl-1,4,5,6-tetrahydro-2-pyrimidinethiol in 420 ml of warm methanol. The reaction mixture is stirred for 2 hours at room temperature and worked up in the manner described unter Example 1 to yield 3-(1-methyl-1,4,5,6-tetrahydro-2-pyrimidinylthio)-indole-2-carboxylic acid hydriodide which melts at 230°-231° after recrystallization from a mixture of methanol, ethyl acetate and ether.

Provenance & Evidence