Iodine → HCID 12934713, compound

Participants

Reaction Steps

A solution of 19.65 g of 2-methylindole in 250 ml of methanol is added to a well-stirred solution of 75 g of potassium iodide and 38 g of iodine in 225 ml of water at room temperature. This mixture is further treated with a solution of 17.4 g of 1,4,5,6-tetrahydro-2-pyrimidinethiol in 350 ml of warm methanol, stirred for 2 hours and worked up in the manner described under Example 1 to yield 2-methyl-3-(1,4,5,6-tetrahydro-2-pyrimidinylthio)-indole hydriodide which melts at 242° after recrystallization from a mixture of methanol and ethyl acetate.

Provenance & Evidence