Iodine → HCID 12934725, compound

Participants

Reaction Steps

A solution of 8.6 g of 1-methylindole-2-carboxylic acid in 250 ml of warm methanol is added to a well-stirred solution of 25 g of potassium iodide and 12.2 g of iodine in 75 ml of water and treated with a solution of 5.8 g of 1,4,5,6-tetrahydro-2-pyrimidinethiol. The reaction is carried out and then worked up in the manner described under Example 1 to yield 1-methyl-3-(1,4,5,6-tetrahydro-2-pyrimidinylthio)-indole-2-carboxylic acid hydriodide which melts at 227° (with decomposition) after recrystallization from a mixture of methanol and ethyl acetate.

Provenance & Evidence