Indole → HCID 12934735, compound

Participants

Reaction Steps

A solution of 12.7 g of iodine and 20 g of potassium iodide in 100 ml of water is added dropwise to a well-stirred mixture of 5.85 g of indole in 20 ml methanol and 6.5 g of 4,5,6,7-tetrahydro-1H-1,3-diazepine-2-thiol in 100 ml methanol. The reaction mixture is stirred at room temperature for 2 hours. The crystalline precipitate formed was filtered off and recrystallized from a mixture of methanol, ethyl acetate and ether to afford 3-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-ylthio)-indole hydriodide which melts at 236° (with decomposition).

Provenance & Evidence