HuagongsheHuagongshe Chemistry Print Report · For research reference only
Urea → 2-Hydroxy-5-[1-hydroxy-2-(isopropylamino)ethyl]benzeneacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | N-(1,1-Dimethylethyl)benzenamine | HCID 254260 | — |
| Reactant | 5-[N-(isopropylamino)glycyl]-2-hydroxyphenylacetonitrile | HCID 21325161 | — |
| Product | 2-Hydroxy-5-[1-hydroxy-2-(isopropylamino)ethyl]benzeneacetonitrile | HCID 21325150 | — |
Reaction Steps
The procedure of Example 1(c) is repeated with substitution of an equimolar amount of isopropylamine for phenyl-t-butylamine in that example. The resulting aminoketone, 5-[N-(isopropylamino)glycyl]-2-hydroxyphenylacetonitrile, is reduced according to the procedure of Example 1(d) to yield 2-hydroxy-5-[1-hydroxy-2-(isopropylamino)ethyl]-benzeneacetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04055658 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-5728f8b512434b87b98c03afd66f01a5 |
| Source note | uspto-grants-1977_10 |