HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Fluorobenzoyl)propionic acid → 3-(3,4-Dichlorophenyl)-2-(2-hydroxyhexyl)-4,5-dihydropyridazin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Fluorobenzoyl)propionic acid | HCID 101359 | — |
| Reactant | 1-Hydrazinylpropan-2-ol | HCID 236167 | — |
| Reactant | 4-(3,4-Dichlorophenyl)-4-oxobutyric acid | HCID 289763 | — |
| Reactant | 2-Hydroxybutylhydrazine | HCID 4113127 | — |
| Reactant | 1-Hydrazino-2-hexanol | HCID 20384305 | — |
| Product | 3-(3,4-Dichlorophenyl)-2-(2-hydroxyhexyl)-4,5-dihydropyridazin | HCID 22751156 | — |
| Product | 3-(p-Fluorophenyl)-2-(2-hydroxyhexyl)-4,5-dihydropyridazin | HCID 22751166 | — |
Reaction Steps
When the above procedure is carried out using equivalent amounts of 3-(p-fluorobenzoyl)-propionic acid and 1-hydrazino-2-hexanol,3-(3,4-dichlorobenzoyl)-propionic acid and 1-hydrazino-2-propanol or 3-(3,4-dichlorobenzoyl)-propionic acid and 1-hydrazino-2-hexanol in place of the 3-(p-chlorobenzoyl)-propionic acid and 1-hydrazino-2-butanol used therein, there is obtained 3-(p-fluorophenyl)-2-(2-hydroxyhexyl)-4,5-dihydropyridazin (2H)-3-one (m.p. 75°-77° C) 3-(3,4-dichlorophenyl)-2-(2-hydroxypropyl)-4,5-dihydropyridazin(2H)-3-one, (m.p. 108.5°-100° C) or 3-(3,4-dichlorophenyl)-2-(2-hydroxyhexyl)-4,5-dihydropyridazin (2H)-3-one (m.p. 80°-81° C) respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04055644 |
| Source dataset | uspto-grants-1977_10 |
| ORD ID | ord-625a0ff4564d4b078f25fdb0c7d39d41 |
| Source note | uspto-grants-1977_10 |