1-Bromo-2-propanol → 6-(3-Methyl-4-chlorophenyl)-2-(2-hydroxybutyl)-4,5-dihydropyridazine

Participants

Reaction Steps

When the above process is carried out using equivalent weights of 6-(p-fluorophenyl)-4,5-dihydropyridazin (2H)-3-one and 1-bromo-2-hexanol, 6-(3,4-dichlorophenyl)-4,5-dihydropyridazin (2H)-3-one-and 1-bromo-2-propanol, 63,4-dichlorophenly)-4,5-dihydropyridazin(2H)-3-one-and 1-bromo-2hexanol, 6-(2-thienyl)-4,5-dihydropyridazin(2H)-3-one and 1-bromo-2-propanol or 6-(2-thienyl)-4,5-dihydropyridazin (2H)-3-one and 1-bromo-2-hexanol in place of the 6-p-chlorophenyl-4,5-dihydropyridazin(2H)-3-one and 1-bromo-2-butanol used therein, there is obtained 6-(p-fluorophenyl)-2-(2-hydroxyhexyl)-4,5-dihydropyridazin(2H)-3-one, 6-(3,4-dichlorphenyl)-2-(2-hydroxypropyl)-4,5-dihydropyridazin (2H)-3-one, 6-(3,4-dichlorophenyl)-2-(2-hydroxyhexyl)-4,5-dihydropyridazin(2H)-3-one, 6-(2-thienyl)-2-(2-hydroxypropyl)-4,5-dihydropyridazin(2H)-3-one or 6-(2-thienyl)-2-(2-hydroxyhexyl)-4,5-dihydropyridazin(2H)-3-one respectively.

Provenance & Evidence