(+/-)-Methyl 2-(2-naphthylmethoxy)-3,3,3-trifluoro-2-methylpropionate → (+/-)-2-(2-Naphthylmethoxy)-3,3,3-trifluoro-2-methylpropionic acid

Participants

Reaction Steps

The above process is repeated with (±)-methyl 2-(6-chloro-2-naphthylmethoxy)-3,3,3-trifluoro-2-methylpropionate, (±)-methyl 2-(2-naphthylmethoxy)-3,3,3-trifluoro-2-methylpropionate or (±)-methyl 2-(1-naphthylmethoxy)-3,3,3-trifluoro-2-methylpropionate except that the reaction is carried out for 41/2, 2 and 21/2 hours respectively to give (±)-2-(6-chloro-2-naphthylmethoxy)-3,3,3-trifluoro-2-methylpropionic acid, m.p. 150°-153° C. (from toluene-cyclohexane), (±)-2-(2-naphthylmethoxy)-3,3,3-trifluoro-2-methylpropionic acid, m.p. 116°-118° C. (from cyclohexane) or (±)-2-(1-naphthylmethoxy)-3,3,3-trifluoro-2-methylpropionic acid, m.p. 82°-84° C. (from light petroleum b.p. 60°-80° C.) respectively.

Provenance & Evidence