Thionyl Chloride → HCID 20314483, compound

Participants

Reaction Steps

A mixture of 2-(4-chlorophenoxy)-3,3,3-trifluoro-2-trifluoromethylpropionic acid (161 mg.), thionyl chloride (200 mg.), dimethylformamide (20 mg.) and light petroleum (2 ml. b.p. 40°-60° C.) is heated under reflux for 15 minutes and the solvent evaporated. Light petroleum (5 ml. is added, and the evaporation repeated. The residue is dissolved in light petroleum, the solution filtered and evaporated to give 2-(4-chlorophenoxy)-3,3,3-trifluoro-2-trifluoromethylpropionyl chloride (151 mg.) as an oil.

Provenance & Evidence