Methanol → HCID 13384244, compound

Participants

Reaction Steps

A mixture of (±)-methyl 2-(4-chlorophenoxy)-3,3,3-trifluoro-2 -methylpropionate (1.41 g.), methanol (4.0 ml.), and 4.5 N-aqueous potassium hydroxide (2.3 ml.) is stirred at ambient temperature for 10 minutes. The resulting solution is diluted with water, washed with ether, acidified with concentrated hydrochloric acid, and extracted with ether. The extract is washed with water, dried with sodium sulphate and evaporated to a residue which is crystallised from light petroleum (b.p. 60°-80° C.) to give (±)-2-(4-chlorophenoxy)-3,3,3-trifluoro-2-methylpropionic acid, m.p. 141°-142° C. (0.7 g.).

Provenance & Evidence