Sodium Hydroxide → HCID 86735170, compound

HRID 973322Notes

Reaction equation

HRID 973322 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:24]=[CH:23][C:11]([CH2:12][O:13][C:14]([CH3:22])([C:18]([F:21])([F:20])[F:19])[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+:26]>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([CH2:12][O:13][C:14]([CH3:22])([C:18]([F:19])([F:20])[F:21])[C:15]([O-:17])=[O:16])=[CH:23][CH:24]=2)=[CH:6][CH:7]=1.[Na+:26]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13384277HCID 13384277, compound

Product 1

HCID 86735170HCID 86735170, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of (±)-2-[4-(4-chlorophenyl)benzyloxy]-3,3,3-trifluoro-2-methylpropionic acid (0.36 g.), N aqueous sodium hydroxide (1.0 ml.) and water (3.0 ml.) is stirred until no more of the acid dissolves. The mixture is filtered, the filtrate is washed with ether and evaporated in vacuo. The residue is crystallised from a mixture of ethyl acetate and light petroleum (b.p. 60°-80° C.) to give (±)-sodium 2-[4-(4-chlorophenyl)benzyloxy]-3,3,3-trifluoro-2-methylpropionate (0.3 g.) m.p. 271°-272° C. (decomposition).

Workup

  1. dissolutiondissolves
  2. filtrationThe mixture is filtered
  3. washthe filtrate is washed with ether
  4. customevaporated in vacuo
  5. customThe residue is crystallised from a mixture of ethyl acetate and light petroleum (b.p. 60°-80° C.)

Sources & evidence

ORD record
ord-6823f62b9a1d432cba98bce09a9c9191
Source dataset
uspto-grants-1977_10
Patent number
US04055595

Reaction notes

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