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HRID973379

反应详情

EQUATION

反应方程式

HRID 973379 的结构方程式

REACTANTS

反应物

2
结构：CCO
HCID702

Ethanol

C2H6O

结构：C[C@H]1O[C@@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]5(C)[C@@H](C7=CC(=O)OC7)CC[C@]65O)C4)O[C@@H]3C)O[C@@H]2C)C[C@H](O)[C@@H]1O
HCID2724385

Digoxin

C41H64O14

PRODUCTS

生成物

1
结构：CO[C@H]1[C@@H](O)C[C@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]5(C)[C@@H](C7=CC(=O)OC7)CC[C@]65O)C4)O[C@@H]3C)O[C@@H]2C)O[C@@H]1C
HCID443946

Methyldigoxin

C42H66O14

PROCEDURE

实验过程

4.75 l. of eluate with 40% ethanol contain 3.91 g. of solid material. The mixture contains all non-reacted digoxin, α-metildigoxin and β-metildigoxin and can again be separated on the column. The following fraction of 5 l. contains 4.73 g. of slightly contaminated β-metildigoxin. If the ethanol content is increased, diethers and higher ethers of digoxin are eluted. The main fraction with metildigoxin is reprecipitated from methanol/water, boiled up with chloroform and stirred up with acetone.

WORKUP

后处理

  1. customcan again be separated on the column
  2. temperatureIf the ethanol content is increased
  3. washdiethers and higher ethers of digoxin are eluted
  4. customThe main fraction with metildigoxin is reprecipitated from methanol/water