4H-Pyrido(1,2-a)pyrimidine-3-acetic acid, 9-((4-acetyl-3-hydroxy-2-propylphenoxy)methyl)-4-oxo- → AS 35

HRID 973383Notes

Reaction equation

HRID 973383 reaction equation
[C:1]([C:4]1[CH:26]=[CH:25][C:7]([O:8][CH2:9][C:10]2[C:15]3=[N:16][CH:17]=[C:18]([CH2:21]C(O)=O)[C:19](=[O:20])[N:14]3[CH:13]=[CH:12][CH:11]=2)=[C:6]([CH2:27][CH2:28][CH3:29])[C:5]=1[OH:30])(=[O:3])[CH3:2].C(C1C=CC(OCC2C3=NC=C(CCC4[NH:57][N:56]=[N:55][N:54]=4)C(=O)N3C=CC=2)=C(CCC)C=1O)(=O)C>>[CH3:29][CH2:28][CH2:27][C:6]1[C:5]([OH:30])=[C:4]([C:1]([CH3:2])=[O:3])[CH:26]=[CH:25][C:7]=1[O:8][CH2:9][C:10]1[C:15]2=[N:16][CH:17]=[C:18]([C:21]3[N:57]=[N:56][NH:55][N:54]=3)[C:19](=[O:20])[N:14]2[CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 30869474H-Pyrido(1,2-a)pyrimidine-3-acetic acid, 9-((4-acetyl-3-hydroxy-2-propylphenoxy)methyl)-4-oxo-HCID 178439663HCID 178439663, compound

Product 1

HCID 130135AS 35

Procedure

Furthermore, [9-(4-acetyl-3-hydroxy-2-n-propylphenoxymethyl)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]acetic acid (to be referred to as AS-148) and 9-[(4-acetyl-3-hydroxy-2-n-propylphenoxy)methyl]-3-[2-(1H-tetrazol-5-yl)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one (to be referred to as AS-163) could not be formed into an aqueous solution as AS-35 could not. The present inventors confirmed the above finding by their own experiments.

Sources & evidence

ORD record
ord-7946eec2a10140cda1b10940826b1dc2
Source dataset
uspto-grants-1991_11
Patent number
US05063061

Reaction notes

Loading…