4'-Hydroxyacetophenone → 1-[4-(Benzyloxy)phenyl]ethan-1-one

Participants

Reaction Steps

27.2 g of 4-hydroxyacetophenone is mixed with 100 ml of dimethylformamide, 25.3 g of benzyl chloride and 30.4 g of potassium carbonate. The resulting mixture is stirred in a stream of nitrogen at 100°-110° C. for 3 hours and then cooled. The cooled mixture is added to about 2 l of ice water to deposit solid. The solid is separated therefrom by filtration and then washed with water until the solid becomes neutral. The washed solid is dried and then recrystallized from 500 ml of ethanol to obtain 38.8 g of 4-benzyloxyacetophenone. Thus obtained 4-benzyloxyacetophenone has a melting point of 92.5°-93° C.

Provenance & Evidence