Ethyl chloroformate → HCID 15079123, compound

HRID 973400Notes

Reaction equation

HRID 973400 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:13]([CH3:19])[CH2:14][C:15](=[O:18])[NH:16][N:17]=3)=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.Cl[C:21]([O:23][CH2:24][CH3:25])=[O:22]>N1C=CC=CC=1>[CH2:24]([O:23][C:21]([NH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:13]([CH3:19])[CH2:14][C:15](=[O:18])[NH:16][N:17]=3)=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1)=[O:22])[CH3:25]

Participants

4

Reactant 2

HCID 10928Ethyl chloroformateHCID 15079122HCID 15079122, compound

Product 1

HCID 15079123HCID 15079123, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Compound 11 (0.20 g) obtained in Example 11 was dissolved in 5 ml of pyridine, and 0.1 ml of ethyl chloroformate was added to the solution. The resulting mixture was stirred at room temperature for 3 hours and then concentrated. Water was added to the residue, and the crystals precipitated were collected by filtration and dried to give 0.21 g (82%) of 6-(4-ethoxycarbonylamino-quinazolin-7-yl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone (Compound 53).

Workup

  1. concentrationconcentrated
  2. additionWater was added to the residue
  3. customthe crystals precipitated
  4. filtrationwere collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-d9c333fe44964cda9f6679e585cd1cf7
Source dataset
uspto-grants-1991_11
Patent number
US05063227

Reaction notes

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