Methylamine → HCID 15079195, compound

Participants

Reaction Steps

In 20 ml of 40% methylamine solution in methanol was suspended 0.50 g of Compound 63 obtained in Example 65. The suspension was heated under reflux with stirring for 4 hours and then concentrated. The residue was subjected to partition between water and chloroform, and the organic layer was dried and concentrated. The residue was crystallized from a mixture of dimethylformamide and water to give 0.38 g (76%) of 4,5-dihydro-5-methyl-6-(4-methylamino2-methylquinazolin-7-yl)-3(2H)-pyridazinone (Compound 64).

Provenance & Evidence