Benzylamine → HCID 15079194, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.76 g of Compound 64 obtained in Example 66, 15 ml of benzylamine and 15 ml of dimethylsulfoxide was stirred at 150° C. for 3 hours, and then concentrated. The residue was subjected to partition between water and chloroform, and the organic layer was dried and concentrated. The residue was purified by column chromatography using 100 g of silica gel to give 0.31 g (32%) of 6-(4-benzylamino-2-methylquinazolin-7-yl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone (Compound 65).

Provenance & Evidence