HCID 178429553, compound → HCID 15079183, compound

HRID 973405Notes

Reaction equation

HRID 973405 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[CH:12]([CH3:18])[CH2:13][C:14](=[O:17])[NH:15][N:16]=3)[CH:9]=2)[CH2:4][NH:3][CH:2]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:18][CH:12]1[C:11]([C:8]2[CH:9]=[C:10]3[C:5]([CH:4]=[N:3][CH:2]=[N:1]3)=[CH:6][CH:7]=2)=[N:16][NH:15][C:14](=[O:17])[CH2:13]1

Participants

4

Reactant 1

HCID 178429553HCID 178429553, compound

Product 1

HCID 15079183HCID 15079183, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

In 20 ml of chloroform was dissolved 0.25 g of Compound 71 obtained in Example 71, and 2.0 g of manganese dioxide was added to the solution, followed by stirring at room temperature for 1 hour. Insoluble substances were filtered off, and the filtrate was concentrated. The residue was crystallized by the addition of diethyl ether to give 0.2 g (83%) of 4,5-dihydro-5-methyl-6-(7-quinazolinyl)-3(2H)-pyridazinone (Compound 54).

Workup

  1. additionwas added to the solution
  2. filtrationInsoluble substances were filtered off
  3. concentrationthe filtrate was concentrated
  4. customThe residue was crystallized by the addition of diethyl ether

Sources & evidence

ORD record
ord-d8a799c6a6bb459180bbddfc50095549
Source dataset
uspto-grants-1991_11
Patent number
US05063227

Reaction notes

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