Toluene → HCID 19989848, compound

Participants

Reaction Steps

To 4.0 g (0.015 mol) of 4-(2-chloroethyl)-3,4-dihydro-2-methylpyrimido[1,6-a]benzimidazol-1(2H)-one in 20 mL of toluene was added 5.0 g (0.0175 mol) of 4-[bis(4-fluorophenyl)methyl]piperidine and 5.0 g (0.05 mol) of triethylamine and the reaction mixture heated to reflux for 24 hr. The reaction mixture was washed with 3×50 mL of 1N NaOH, dried over Na2SO4, filtered, and concentrated by rotary evaporation. The residue was subjected to preparative HPLC using ethanol as the eluent and silica gel as the stationary phase. Like fractions were combined and concentrated by rotary evaporation to give 3.7 g (49%) of an analytically pure oil.

Provenance & Evidence