HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiophenol → alpha-[[(2-Amino-phenyl)-thio]-methyl]-4-methoxy benzeneacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiophenol | HCID 8713 | — |
| Reactant | 2-(4-Methoxyphenyl)prop-2-enoic acid | HCID 14573787 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | alpha-[[(2-Amino-phenyl)-thio]-methyl]-4-methoxy benzeneacetic acid | HCID 15052122 | — |
Reaction Steps
A solution of 125 ml of ethanol, 8.9 g of 4-methoxy-α-methylene benzeneacetic acid and 5.35 ml of 2-amino thiophenol was refluxed for 7 hours. The ethanol was evaporated off and the residue was crystallized from 500 ml of isopropyl ether to obtain 11 g of the desired product melting at 118° C. and used as is for the following step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05063225 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-d095d8bc044340b2b18fbd28e653b24d |
| Source note | uspto-grants-1991_11 |