Potassium Hydroxide → HCID 10921070, compound

Participants

Reaction Steps

765 ml of an aqueous solution (0.33M) of potassium hydroxide were added to a solution of 21 g of the product of Step B in 1 liter of tetrahydrofuran and the mixture was stirred for 48 hours at ambient temperature. The tetrahydrofuran was evaporated off and the aqueous phase was cooled and acidified with 2N hydrochloric acid. Separation was carried out, then washing with water and drying to obtain 16.8 g of the product which was used as is for the following step. An analytical sample was prepared by hot and cold crystallization of 1.6 g of product from 30 ml of isopropyl ether to obtain 0.8 g of the product melting at 146° C.

Provenance & Evidence