Dicyclohexylcarbodiimide → HCID 15052144, compound

Participants

Reaction Steps

11.7 g of the acid of Step D, 7.95 g of dicyclohexylcarbodiimide and 350 ml of ethanol were stirred for 6 hours at ambient temperature and after evaporation to dryness, the residue was taken up in 1500 ml of methylene chloride. The insoluble part was filtered off and the filtrate was concentrated to dryness. The residue was taken up in 1500 ml of ethanol and separation was effected to obtain 9.6 g of the desired product melting at 219° C. which was used as is for the following step. An analytical sample was prepared by crystallizing 350 mg of product from 40 ml of ethanol to obtain 240 mg of the desired structure melting at 223° C.

Provenance & Evidence