反应详情

6.8 g of the product of Step A were dissolved in 136 ml of a mixture of equal parts of water, of acetic acid and sulfuric acid and the mixture was stirred for 19 hours at ambient temperature. 400 ml of water were added slowly with stirring for 10 minutes, and separation was effected to obtain 5.3 g of the expected product melting at 180° C. which was used as is for following step. An analytical sample was prepared by two successive crystallizations from 20 volumes of ether at reflux starting with 2.7 g of the acid to obtain 1.15 g of the product melting at 190° C. (approx.).

1. stirringwith stirring for 10 minutes
2. customseparation