2-Aminothiophenol → HCID 54486421, compound

Participants

Reaction Steps

20.41 g of aminothiophenol were added all at once to a solution of 43 g of α-methylene-4-(trifluoromethyl)-benzene acetic acid [J. Med. Chem. (1969), Vol. 12 (3), p. 477 to 480] in 300 ml of ethanol, and the mixture was refluxed for 2 hours. The ethanol was evaporated off and the residue was taken up in 600 ml of ethyl ether and partially concentrated to 300 ml. 200 ml of isopropyl ether were added with concentration to 100 ml and cooled for 30 minutes in ice-cooled water. The crystallized product was separated off, washed with isopropyl ether and dried under reduced pressure at 100° C. to obtain 21.9 g of expected product melting at approx. 138° C.

Provenance & Evidence