Lithium hydroxide, monohydrate → HCID 19989771, compound

Participants

Reaction Steps

The resultant compound from Example 46 (100.0 mg, 0.409 mmol) in dioxane (2 ml) at 0° C. was treated with LiOH.H2O (22.0 mg, 0.524 mmol) in water (1 ml). After 1 h at 0° C. and 30 min at room temperature the solvent was evaporated and the residue was taken up in water, the pH was adjusted to pH 3-4, and the mixture was extracted with CHCl3 which was dried over Na2SO4 and evaporated to afford 96 mg (100%) of a solid. 1H NMR (CDCl3) δ7.56 (d,1H), 7.10-7.35 (m,6H), 6.26 (dd,1H), 4.30 (m,2H), 3.34 (m,1H), 3.12 (dd,1H), 2.72 (dd,1H).

Provenance & Evidence