Betahistine → HCID 15018133, compound

Participants

Reaction Steps

To the resultant compound from Example 62 (1 mmol) in methylene chloride (10 mL) at -10° C. was added triethylamine (1.2 mmol) and 2-(2-methylaminoethyl)pyridine (1 mmol). After 30 min the mixture was evaporated, suspended in ethyl acetate, washed with saturated NaHCO3 solution, water, and brine, and then dried over Na2SO4 and evaporated. Chromatography of the residue on silica gel afforded the desired product.

Provenance & Evidence