HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 178503370, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 3-(Methylthio)-1,2,4-triazol-5-amine | HCID 78471 | — |
| Reactant | ethyl 3-oxotetrahydro-2H-thiopyran-2-carboxylate | HCID 12269128 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 178503370 | HCID 178503370 | 51.1% |
Reaction Steps
To the solution of 6.5 g (0.05 mole) of 5-amino-3-methylthio-1H-1,2,4-triazole, 2.5 ml of acetic acid and 12.5 ml of dimethylformamide 9.4 g (0.05 mole) of ethyl 3-oxo-3,4,5,6-tetrahydro-2H-thiopyrane-2-carboxylate are added and the reaction mixture is boiled for 60 minutes. The precipitated product is filtered off from the hot solution, then washed with acetic acid and i-propanol and recrystallized from dimethylformamide. Thus 6.5 g (51.1%) of 2-methylthio-5,7,8,9-tetrahydrothiopyrano[3,2-d]-1,2,4-triazolo[1,5-a]pyrimidine-5(10H)-one are obtained. M.p.: higher than 350° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05064826 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-56224d54a21c4cbc816c24544ca729b0 |
| Source note | uspto-grants-1991_11 |