HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloropyridine → 4-Chloro-2-(3-bromophenyl)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloropyridine | HCID 12288 | — |
| Reactant | Phenyl chloroformate | HCID 15891 | — |
| Reactant | HCID 178506674 | HCID 178506674 | — |
| Reactant | HCID 178507885 | HCID 178507885 | — |
| Product | 4-Chloro-2-(3-bromophenyl)-pyridine | HCID 19988650 | — |
Reaction Steps
Starting from 3-bromophenyllithium, 4-chloropyridine and chloroformic acid phenyl ester (for the acylation of the pyridine nitrogen), the title compound is prepared analogously to J. Org. Chem. 50, 4410 (1985). A corresponding 1-acyl-1,2-dihydropyridine is formed as intermediate and is aromatised by reaction with o-chloroanil (=3,4,5,6-tetrachloro-1,2-benzoquinone) to form the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05064832 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-90d99d4c422947d3b0e5dabb1c6dab44 |
| Source note | uspto-grants-1991_11 |