HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 10265671, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 10086136 | HCID 10086136 | — |
| Product | HCID 10265671 | HCID 10265671 | 31% |
Reaction Steps
8-Methoxy-4-(2-methylphenylamino)-2-chloroquinazoline (1.8 g, 0.006 mol) was dissolved in ethanolic ammonia and heated in a sealed vessel at 120° for 3 hours. After cooling, removal of excess solvent and chromatography (silica gel, 2% methanolic ammonia in chloroform) the 2 amino-4-(2-methylphenylamino)-8-methoxyquinazoline was isolated as crystals (0.52 g, 31%) from ethanol, m.p. 218°-220°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05064833 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-ef14af10347e42269a269838677330f6 |
| Source note | uspto-grants-1991_11 |