Ethylamine → HCID 10378838, compound

HRID 973566Notes

Reaction equation

HRID 973566 reaction equation
Cl[C:2]1[N:11]=[C:10](CNC2C=CC=CC=2C)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:21]([NH2:23])[CH3:22]>C(O)C>[CH2:21]([NH:23][C:2]1[N:11]=[C:10]([NH:3][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=2[CH3:10])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1)[CH3:22]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 19988707HCID 19988707, compound

Product 1

HCID 10378838HCID 10378838, compoundYield 33%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

2-Chloro-4-(2-methylphenylaminomethyl)quinazoline (5.00 g, 0.0185 mol) and ethylamine in ethanol (33%, 30 ml) were dissolved in ethanol (35 ml) placed in a sealed vessel and heated for 5 hours at 130°. After cooling and removal of excess solvent in vacuo the residue afforded crystals of 2-ethylamino-4-(2-methylphenylamino)quinazoline (1.7 g, 33%) from ethanol/water, m.p. 127°-129°.

Workup

  1. customplaced in a sealed vessel
  2. temperatureheated for 5 hours at 130°
  3. temperatureAfter cooling
  4. customremoval of excess solvent in vacuo the residue

Sources & evidence

ORD record
ord-14ff26d078e5468fa416be0168601686
Source dataset
uspto-grants-1991_11
Patent number
US05064833

Reaction notes

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