O-Toluidine → HCID 67925953, compound

HRID 973582Notes

Reaction equation

HRID 973582 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([N:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[C:9]2[C:4](=[C:5]([F:20])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:21][C:22]1[C:23]([CH3:28])=[CH:24][CH:25]=[CH:26][CH:27]=1>>[ClH:1].[CH3:28][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[NH:21][C:2]1[N:11]=[C:10]([N:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[C:9]2[C:4](=[C:5]([F:20])[CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 7242O-ToluidineHCID 10401816HCID 10401816, compound

Product 1

HCID 67925953HCID 67925953, compound

Procedure

In a procedure analogous to that of Example 41 2-chloro-4-(N-methylphenylamino)-8-fluoroquinazoline and o-toluidine are reacted together to give the title compound. The starting 2-chloro-4-(N-methylphenylamino)8-fluoroquinazoline is prepared via procedures analogous to those of Example 1.

Sources & evidence

ORD record
ord-fc2c51f630ae4f33932fbc0203c7bfb6
Source dataset
uspto-grants-1991_11
Patent number
US05064833

Reaction notes

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