4-Fluoro-2-methylaniline → HCID 11740242, compound

HRID 973583Notes

Reaction equation

HRID 973583 reaction equation
Cl[C:2]1[N:11]=[C:10]([N:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[C:9]2[C:4](=[C:5]([F:20])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:21][C:22]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:23]=1[NH2:24]>>[CH3:21][C:22]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:23]=1[NH:24][C:2]1[N:11]=[C:10]([N:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[C:9]2[C:4](=[C:5]([F:20])[CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 10401816HCID 10401816, compound

Product 1

HCID 11740242HCID 11740242, compound

Procedure

In a procedure analogous to that of Example 41 2-chloro-4-(N-methylphenylamino)-8-fluoroquinazoline and 2-methyl-4-fluoroaniline are reacted together to give the title compound.

Sources & evidence

ORD record
ord-f6e354c6a5994dbc83bef1ccf20d60e7
Source dataset
uspto-grants-1991_11
Patent number
US05064833

Reaction notes

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