Boron tribromide → HCID 21650385, compound

HRID 973586Notes

Reaction equation

[CH3:1][N:2]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13]C)[CH:11]=2)[N:6]=[C:5]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[N:4]=1.B(Br)(Br)[Br:30]>>[BrH:30].[CH3:1][N:2]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([OH:13])[CH:11]=2)[N:6]=[C:5]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[N:4]=1

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 10339143HCID 10339143, compound

Product 1

HCID 21650385HCID 21650385, compoundYield 43%

Procedure

4-(N-Methylphenylamino)-2-[(2-methylphenyl)amino]6-methoxyquinazoline (prepared as described in co-pending EP-A-88311461.3) (3.0 g, 0.0074 mol) and boron tribromide (9.2 g, 0.037 mol) were reacted together under the conditions described in Example 3 to give the title compound (1.39 g), crystallised from methanol/diethyl ether as its hydrobromide salt, m.p. 172°-174°.

Sources & evidence

ORD record: ord-8a4a5a48daa8457f9953ee8a51a7a862
Source dataset: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05064833

Reaction notes

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