Sodium Hydroxide → HCID 9964768, compound

Participants

Reaction Steps

0.5 g of ethyl 3-amino-2-hydroxy-propyl(diethoxymethyl)-phosphinate is dissolved in 5 ml of ethanol and this solution is added to a solution of 0.14 g of sodium hydroxide in 2 ml of water. This mixture is then heated to 60° for a period of 3 hours, cooled to room temperature and the solvent evaporated under reduced pressure. The oily residue is passed down an Ion Exchange Resin (DOWEX® 50W-X8 H+) using de-ionised water as eluant. Ninhydrin-positive fractions are combined and evaporated to give 3-amino-2-hydroxy-propyl(diethoxymethyl)phosphinic acid, m.p. 214°-215° (dec.), 31P-NMR : δ=+30.9 ppm (D2O).

Provenance & Evidence